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doi: 10.1016/0960-0760(92)90170-n CrossRefGoogle ScholarPubMed Krsmanovic, L

transdermal patches of the present invention with lower and higher doses of GHK-Cu incorporating a gel reservoir composition provided sustained action and at the same time achieved steady state concentration in an hour which lasted for at least 24 hrs

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SCHEME 1 The final compounds -L-H-Glu(L-Glu-OH)OH 2 (( S , S ) 4-amino-4-carboxybutanoyl) glutamic acid) as chlorhydrate salt were obtained in 90% yield by removing N -BOC and tert butyl esters protecting groups in acidic conditions using HCl 4N aqueous solution in dioxane (Scheme 2)